The definitive standard for medical and scientific manuscripts. Based on the AMA Manual of Style, 11th Edition — used by JAMA, NEJM, and leading biomedical journals.
The AMA Manual of Style, 11th Edition (Feb 2020), is the global rulebook for medical and scientific publishing. It dictates how to cite sources, abbreviate journals, present data, and report statistics, requirements enforced by virtually every peer-reviewed medical journal, grant agency, and medical school.
When instructions say “use AMA format,” they mean your references, tables, and ethical disclosures must match this manual exactly. Page layout (margins, fonts, headings) is left to your professor or journal’s own checklist, so always double-check their add-on rules before you submit.
Official Source: AMA Manual of Style 11th Edition — Verified December 11, 2025
These requirements are non-negotiable for medical journal submission:
These common errors cause manuscript rejection. Items marked green are auto-fixed by SimpleFormat.
AMA 11th edition mentions serif for body text and suggests sans-serif for headings, but check individual journal requirements. Times New Roman 12pt is commonly used in medical manuscripts.
Source: AMA Manual of Style, 11th ed. — Verified December 10, 2025
Traditional serif font universally accepted in medical publishing. Most medical journals and schools expect this font for manuscripts.
Arial is an acceptable sans-serif option for headings according to AMA’s flexible guidance.
Calibri may be used for headings; AMA does not mandate this font, though it is commonly readable on screens.
AMA uses 4 heading levels. Levels 1-3 are standalone headings with text on the next line. Level 4 is a 'run-in' heading where text continues on the same line.
AMA uses superscript Arabic numerals for citations. Users are responsible for numbering citations in order of appearance.
Example: "Diabetes affects millions of people worldwide¹. Recent studies have shown improvements¹⁻³. Multiple groups confirmed these findings¹,³,⁵: reduced HbA1c and weight loss."
Medical journal references must be flush left with NO hanging indent. This is a common formatting error in medical manuscripts.
1. Smith JM, Johnson AB, Williams CD. Treatment outcomes in type 2 diabetes. JAMA. 2020;323(15):1456-1463. doi:10.1001/jama.2020.1234
We automate the time-consuming, tedious formatting work so you can focus on what really matters: your research and writing. Every margin, indent, spacing rule, and micro-format detail is applied according to official AMA 11 specifications.
Here's what we handle automatically when you use our guided wizard:
Note: These are standard AMA 11 defaults. Thesis/dissertation papers, specific journals, and institutions may have different requirements — full customization options are available in the wizard.
Bottom line: Quality In = Quality Out (The opposite is also true)
We handle formatting, not content creation. Here's what remains your responsibility:
Unlike standard journal papers, theses and dissertations have additional structural requirements. We handle these automatically:
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See exactly what SimpleFormat transforms. Before → After.
70 frequently asked questions about AMA Manual of Style 11th Edition formatting
AMA recommends serif fonts for body text and sans-serif for headings. The standard is 12-pt Times New Roman for body text with Arial for headings. SimpleFormat automatically applies these AMA-compliant font settings when formatting your medical manuscript.
Source: AMA Manual of Style 11th ed., Chapter 20; Applied by: SimpleFormat Pro
AMA 11 requires 1-inch (2.5 cm) margins on all sides. The right margin should be unjustified (ragged right). SimpleFormat applies correct AMA margins automatically, including 1.5-inch binding margins for theses and dissertations.
Source: AMA Manual of Style 11th ed., Chapter 20.1; Applied by: SimpleFormat Pro
Double-space body text; single-space abstracts, block quotes, tables, figures, and references; double-space between reference entries. This complex spacing pattern is error-prone when done manually. SimpleFormat handles all AMA spacing rules automatically.
Source: AMA Manual of Style 11th ed., Chapter 20.1; Applied by: SimpleFormat Pro
Use consecutive superscript Arabic numerals (1, 2, 3). Place citation numbers outside periods and commas, but inside colons and semicolons. The first cited source is numbered 1 and reuses that number throughout. SimpleFormat auto-detects and formats superscript citations correctly.
Source: AMA Manual of Style 11th ed., Chapter 3.1; Applied by: SimpleFormat Pro
Use commas for non-consecutive numbers (e.g., 1,3,5) and hyphens for consecutive ranges (e.g., 1-4). Example: "as reported previously.1,4-7,19" SimpleFormat preserves your citation groupings while ensuring correct superscript formatting.
Source: AMA Manual of Style 11th ed., Chapter 3.3; Applied by: SimpleFormat Pro
Number references in order of first citation (not alphabetically). References are flush left with NO hanging indent—this is the #1 formatting mistake in medical manuscripts. Single-space within entries, double-space between. SimpleFormat automatically formats references flush-left without hanging indents.
Source: AMA Manual of Style 11th ed., Chapter 3.5; Applied by: SimpleFormat Pro
Format: Author AA, Author BB. Article title. Abbreviated Journal Name. Year;Vol(Issue):Pages. doi:10.xxxx/xxxxx. Example: Smith AB, Jones CD. Treatment outcomes in diabetes. JAMA. 2020;324(5):412-418. doi:10.1001/jama.2020.1234
Source: AMA Manual of Style 11th ed., Chapter 3.11.1; Applied by: SimpleFormat Pro
In the reference list, list the first 3 authors followed by "et al" (no period after "al"). In-text narrative mentions use first author + "et al" for 3 or more authors. Note: AMA uses "et al" not "et al." — SimpleFormat applies this correctly.
Source: AMA Manual of Style 11th ed., Chapter 3.11.1; Applied by: SimpleFormat Pro
AMA defines 4 heading levels: Level 1 (Bold, Title Case, Left), Level 2 (Bold, Title Case, Left), Level 3 (Bold Italic, Title Case, Left), Level 4 (Italic, run-in with period, Sentence case). Sans-serif fonts (Arial) are suggested for headings but not required. SimpleFormat applies correct heading hierarchy automatically based on your document structure.
Source: AMA Manual of Style 11th ed., Chapter 20.2; Applied by: SimpleFormat Pro
Number tables consecutively (Table 1, Table 2). The label and number are bold; the title is sentence case, not bold. Use horizontal rules only (no vertical lines). Table footnotes use superscript lowercase letters (a, b, c), placed below the table.
Source: AMA Manual of Style 11th ed., Chapter 4.1; Applied by: SimpleFormat Pro
Number figures consecutively (Figure 1, Figure 2). Place the number and title above the figure. The legend or caption (≤40 words) goes below. For a single figure, use "Figure" without a number. SimpleFormat positions figure labels correctly per AMA requirements.
Source: AMA Manual of Style 11th ed., Chapter 4.2; Applied by: SimpleFormat Pro
DOI is preferred. Format as doi:10.xxxx/xxxxx (no https:// prefix, no final period). If no DOI exists, include the full URL plus access date. SimpleFormat preserves your DOIs in the correct AMA format.
Source: AMA Manual of Style 11th ed., Chapter 3.15.2; Applied by: SimpleFormat Pro
Format: Author AA, Author BB. Book Title. Edition ed. Publisher; Year. Example: Drake RL, Vogl W. Gray's Anatomy for Students. 4th ed. Elsevier; 2020. Note: no comma before publisher, semicolon before year.
Source: AMA Manual of Style 11th ed., Chapter 3.12.1; Applied by: SimpleFormat Pro
Format: Author AA. Chapter title. In: Editor BB, ed. Book Title. Edition ed. Publisher; Year:pages. Example: Smith JV. Shoulder dislocations. In: Fowler GC, ed. Procedures for Primary Care. Elsevier; 2020:1163-1167.
Source: AMA Manual of Style 11th ed., Chapter 3.12.4; Applied by: SimpleFormat Pro
Short quotes: use double quotation marks with page number in parentheses after the superscript citation (no space). Block quotes (4+ lines): single-space, indent 0.5 inches from left margin, no quotation marks. SimpleFormat handles block quote formatting automatically.
Source: AMA Manual of Style 11th ed., Chapter 8.6; Applied by: SimpleFormat Pro
Original research uses structured abstracts with sections: Objective, Methods, Results, Conclusions. Maximum 250 words. Do not cite references, figures, or tables in the abstract. Do not repeat the title verbatim. SimpleFormat supports both structured and unstructured abstract formats.
Source: AMA Manual of Style 11th ed., Chapter 2.4; Applied by: SimpleFormat Pro
Center content vertically: paper title (bold, 14pt), author names with middle initials, institutional affiliations. Exclude honorifics (Dr., PhD, MD). Double-space all elements. SimpleFormat generates AMA-compliant title pages automatically based on your author information.
Source: AMA Manual of Style 11th ed., Chapter 2.1-2.3; Applied by: SimpleFormat Pro
Format: Author/Organization. Page title. Website Name. Published date. Updated date. Accessed date. URL. Example: Centers for Disease Control and Prevention. COVID-19 guidelines. CDC.gov. Updated July 24, 2020. Accessed August 3, 2020. https://www.cdc.gov/coronavirus
Source: AMA Manual of Style 11th ed., Chapter 3.15.1; Applied by: SimpleFormat Pro
Spell out abbreviations on first use, even common ones like HIV or FDA. Do not use periods in abbreviations (HIV not H.I.V.). Avoid abbreviations in titles. "Et al" has no period after "al" in AMA style.
Source: AMA Manual of Style 11th ed., Chapter 13; Applied by: SimpleFormat Pro
Page numbers go in the upper right corner, starting with the title page as page 1. A running head (shortened title ≤45 characters) may appear in the upper left. SimpleFormat configures headers with page numbers and running heads automatically.
Source: AMA Manual of Style 11th ed., Chapter 20.1; Applied by: SimpleFormat Pro
Format: Author(s). Article title. Abbreviated Journal Name. Year;vol(issue):pages. doi:10.xxxx/xxxxx. No final period after the DOI. Use NLM/PubMed journal abbreviations.
Source: AMA Manual of Style 11th ed., Chapter 3.11.1; Applied by: SimpleFormat Pro
Include the full URL plus access date: Accessed Month Day, Year. URL (no final period after URL). Example: Accessed January 15, 2024. https://www.example.com/article
Source: AMA Manual of Style 11th ed., Chapter 3.15.2; Applied by: SimpleFormat Pro
Place superscript numbers outside periods and commas, but inside colons and semicolons. Number citations consecutively in order of first appearance. Example: "...as shown previously.1,2" SimpleFormat auto-positions citation numbers correctly.
Source: AMA Manual of Style 11th ed., Chapter 3.1; Applied by: SimpleFormat Pro
Spell out the full organization name in the reference list. In text, you may abbreviate after first mention if the abbreviation is well-known. Example: World Health Organization (WHO) on first use, then WHO subsequently.
Source: AMA Manual of Style 11th ed., Chapter 3.11.1; Applied by: SimpleFormat Pro
Start the reference with the article or page title. Never use "Anonymous" unless it is explicitly listed as the author in the original source.
Source: AMA Manual of Style 11th ed., Chapter 3.11.1; Applied by: SimpleFormat Pro
Use surname followed by initials with no spaces or periods between initials: Smith JA, not Smith, J. A. Separate multiple authors with commas. List up to 3 authors before using et al.
Source: AMA Manual of Style 11th ed., Chapter 3.11.1; Applied by: SimpleFormat Pro
No. Write the edition as "5th ed." and format volume/issue as 2025;25(1):15-22. No "Vol." prefix is used in AMA reference formatting.
Source: AMA Manual of Style 11th ed., Chapter 3.11.1; Applied by: SimpleFormat Pro
Yes. Italicize journal titles and use standard NLM/PubMed abbreviations. Example: JAMA, N Engl J Med, Ann Intern Med. SimpleFormat preserves your journal title formatting.
Source: AMA Manual of Style 11th ed., Chapter 3.11.1; Applied by: SimpleFormat Pro
Format: Author. Book Title. #th ed. Publisher; Year. Accessed Month Day, Year. URL. Include the access date and URL for electronic books.
Source: AMA Manual of Style 11th ed., Chapter 3.12.10; Applied by: SimpleFormat Pro
Format: Instructor Name. Lecture Title. PowerPoint presented at: Course Code; Date; University, City. This format applies to unpublished educational materials.
Source: AMA Manual of Style 11th ed., Chapter 3.15.8; Applied by: SimpleFormat Pro
Format: Author. Article title. Newspaper Name. Month Day, Year. Accessed Month Day, Year. URL. Include both publication date and access date for online newspaper articles.
Source: AMA Manual of Style 11th ed., Chapter 3.14; Applied by: SimpleFormat Pro
Format: Author. Article title. Magazine Name. Year;vol(issue):pages. Accessed Month Day, Year. URL. Include database URL if not directly accessible online.
Source: AMA Manual of Style 11th ed., Chapter 3.14; Applied by: SimpleFormat Pro
Format: Author. Article title. Preprint. Published online Month Day, Year. doi:xxxxx. Use "Preprint" as the source indicator for non-peer-reviewed pre-prints.
Source: AMA Manual of Style 11th ed., Chapter 3.11.8; Applied by: SimpleFormat Pro
AMA does not recognize AI as an author. Cite AI tools as software in Methods: Software Name. Version. Publisher; Year. Accessed Month Day, Year. URL. Disclose AI use per journal requirements.
Source: AMA Manual of Style 11th ed., Chapter 3.13 + AMA guidance updates; Applied by: SimpleFormat Pro
While AMA is flexible on fonts, medical journals typically require 12-pt Times New Roman, double-spaced, with 1-inch (2.5 cm) margins. SimpleFormat applies these standard settings automatically.
Source: AMA Manual of Style 11th ed., Chapter 20; Applied by: SimpleFormat Pro
The running head is a shortened version of your title (≤45 characters) placed flush left in the header. Page numbers appear flush right. SimpleFormat configures running heads automatically based on your title.
Source: AMA Manual of Style 11th ed., Chapter 20.1; Applied by: SimpleFormat Pro
Use standard round bullets. Keep lists left-aligned at the normal paragraph margin. Do not add extra indentation. Maintain consistent punctuation (periods for complete sentences, none for fragments).
Source: AMA Manual of Style 11th ed., Chapter 8.5; Applied by: SimpleFormat Pro
Both placements are acceptable. Inline: Table 1, Figure 1 near first mention. Appended: Table A1, Figure A1 after references. Follow your target journal's preference. SimpleFormat supports both configurations.
Source: AMA Manual of Style 11th ed., Chapter 4; Applied by: SimpleFormat Pro
Include the author's name, the label "Corresponding author:" and the email address. Place this on the title page or in a footnote, depending on journal requirements.
Source: AMA Manual of Style 11th ed., Chapter 2.3; Applied by: SimpleFormat Pro
AMA heading hierarchy is indicated by formatting (bold, bold italic, italic) and positioning (left-aligned or run-in) rather than font size changes. All levels use the same base font size. Introduction, Methods, Results, Discussion are Level 1 headings. SimpleFormat applies correct AMA heading formatting.
Source: AMA Manual of Style 11th ed., Chapter 20.2; Applied by: SimpleFormat Pro
Yes. Most medical journals require 3-5 keywords for indexing in MEDLINE/PubMed. Place keywords below the abstract. Use MeSH terms when possible for optimal discoverability.
Source: AMA Manual of Style 11th ed., Chapter 2.4; Applied by: SimpleFormat Pro
Hierarchy is shown through formatting (bold, bold italic, italic) and positioning (left-aligned vs run-in)—not font size. Introduction, Methods, Results, Discussion are Level 1 headings (bold, title case, left-aligned).
Source: AMA Manual of Style 11th ed., Chapter 20.2; Applied by: SimpleFormat Pro
AMA does not mandate paragraph indentation. Flush-left paragraphs with space between them are acceptable. If indenting, use 0.5-inch first-line indent. SimpleFormat supports both styles.
Source: AMA Manual of Style 11th ed., Chapter 20.1; Applied by: SimpleFormat Pro
Preserve em-dashes as written. Some publishers prefer en-dashes with spaces. Check journal guidelines. SimpleFormat preserves your dash formatting during document processing.
Source: AMA Manual of Style 11th ed., Chapter 8.3; Applied by: SimpleFormat Pro
Yes. The abstract typically begins on page 2 (after the title page). This is standard for medical journal submissions.
Source: AMA Manual of Style 11th ed., Chapter 2.4; Applied by: SimpleFormat Pro
For many medical journals, major sections (Methods, Results, Discussion) should begin on new pages. This is recommended but not universally required. Check your target journal's guidelines.
Source: AMA Manual of Style 11th ed., Chapter 20; Applied by: SimpleFormat Pro
Figure legends should be concise—40 words or less per AMA guidelines. Place the legend below the figure. Detailed methodology belongs in the Methods section, not the figure legend.
Source: AMA Manual of Style 11th ed., Chapter 4.2.3; Applied by: SimpleFormat Pro
Running heads must be ≤45 characters including spaces. Abbreviations are acceptable if meaning remains clear. SimpleFormat warns you if your running head exceeds the limit.
Source: AMA Manual of Style 11th ed., Chapter 20.1; Applied by: SimpleFormat Pro
Use superscript lowercase letters (a, b, c) rather than numbers or symbols. Place footnotes immediately below the table. Define abbreviations used in the table in footnotes.
Source: AMA Manual of Style 11th ed., Chapter 4.1.6; Applied by: SimpleFormat Pro
Format: Software Name. Version. Publisher; Year. Accessed Month Day, Year. URL (if applicable). Example: SPSS Statistics. Version 28.0. IBM Corp; 2021.
Source: AMA Manual of Style 11th ed., Chapter 3.13.12; Applied by: SimpleFormat Pro
IMRaD stands for Introduction, Methods, Results, and Discussion. This is the standard structure for original research articles reporting new empirical findings. Most original research papers have 30-50 references. SimpleFormat supports full IMRaD document structure with correct AMA heading formatting.
Source: AMA Manual of Style 11th ed., Chapter 1; Applied by: SimpleFormat Pro
Systematic reviews follow PRISMA guidelines with sections: Introduction, Methods (search strategy, inclusion criteria), Results (PRISMA flow diagram, meta-analysis), Discussion, and Conclusions. Typically 100-200 references. SimpleFormat supports systematic review structure with proper PRISMA section formatting.
Source: AMA Manual of Style 11th ed., Chapter 1 + PRISMA guidelines; Applied by: SimpleFormat Pro
Literature reviews synthesize existing research with Introduction, themed body sections, and Conclusion. Typically 15-30 references. Unlike systematic reviews, methodology is flexible and narrative synthesis is acceptable. SimpleFormat formats literature reviews with thematic heading structures.
Source: AMA Manual of Style 11th ed., Chapter 1; Applied by: SimpleFormat Pro
Case reports follow CARE guidelines: Introduction, Case Presentation (patient history, findings, timeline), Discussion, and Conclusion. Typically 10-20 references. Patient consent and de-identification are required. SimpleFormat supports CARE-compliant case report formatting.
Source: AMA Manual of Style 11th ed., Chapter 1 + CARE guidelines; Applied by: SimpleFormat Pro
Medical essays use Introduction, Body, and Conclusion structure. Typically 5-15 references. Standard AMA formatting applies: double-spaced, 1-inch margins, superscript citations. SimpleFormat formats medical essays with proper AMA styling in minutes.
Source: AMA Manual of Style 11th ed., Chapters 1, 20; Applied by: SimpleFormat Pro
Master's theses require: Title page, Abstract, Table of Contents, List of Tables/Figures. Optional: Acknowledgments, List of Abbreviations. Use Roman numerals for front matter (ii, iii, iv), Arabic for body (1, 2, 3). SimpleFormat generates complete thesis front matter with correct page numbering automatically.
Source: AMA Manual of Style 11th ed., Chapter 2 + institutional guidelines; Applied by: SimpleFormat Pro
Doctoral dissertations require extensive front matter: Title page, Copyright page, Committee/Approval page, Abstract, Dedication, Acknowledgments, Table of Contents, Lists of Tables/Figures/Abbreviations. Typically 100-300 references across 7+ chapters. SimpleFormat supports full dissertation formatting with auto-generated front matter.
Source: AMA Manual of Style 11th ed., Chapter 2 + institutional guidelines; Applied by: SimpleFormat Pro
White papers are professional reports presenting a problem and proposed solution. Structure: Executive Summary, Introduction, Problem Statement, Solution/Recommendations, Conclusion. Typically 15-40 references. Same AMA citation style applies. SimpleFormat formats white papers with professional layouts.
Source: AMA Manual of Style 11th ed., Chapters 1, 3; Applied by: SimpleFormat Pro
Typical reference ranges: Essay 5-15, Case Report 10-20, Literature Review 15-30, Original Research 30-50, White Paper 15-40, Master's Thesis 50-150, Systematic Review 100-200, Doctoral Dissertation 100-300. These are guidelines, not strict limits.
Source: AMA Manual of Style 11th ed. + journal submission guidelines; Applied by: SimpleFormat Pro
Yes. SimpleFormat Pro supports Original Research (IMRaD), Systematic Reviews (PRISMA), Literature Reviews, Case Reports (CARE), Essays, Master's Theses, Doctoral Dissertations, and White Papers—all formatted to AMA 11th Edition specifications with automatic front matter generation.
Source: SimpleFormat Pro; Applied by: SimpleFormat Pro
SimpleFormat Pro formats your entire medical manuscript to AMA 11 specifications in minutes. Paste your content, select your paper type, and download a perfectly formatted Word document. No manual formatting required.
Source: SimpleFormat Pro; Applied by: SimpleFormat Pro
Professional medical editors charge $100-500+ per document for AMA formatting. SimpleFormat Pro offers instant AMA 11 formatting free for up to 5 pages, then from $9.99—less than 1/10th the cost with immediate results. No subscriptions, no hourly rates.
Source: SimpleFormat Pro; Applied by: SimpleFormat Pro
Yes. SimpleFormat Pro is an online AMA 11 formatting tool that handles citations, references, P values, SI units, headings, and all AMA requirements automatically. Paste your content and download a perfectly formatted version in minutes.
Source: SimpleFormat Pro; Applied by: SimpleFormat Pro
The top mistakes are: (1) hanging indents in references (AMA requires flush-left), (2) wrong P value format (should be italic P with no leading zero: P = .05), (3) missing non-breaking spaces in SI units (100 mg not 100mg), (4) wrong citation placement, (5) alphabetizing references (should be numbered by citation order). SimpleFormat auto-corrects all of these.
Source: AMA Manual of Style 11th ed., Chapters 3, 18, 19; Applied by: SimpleFormat Pro
Use italic capital P, no leading zero for values less than 1: P = .05, P < .001. For exact values, report to 2-3 significant digits. This is one of the most common formatting errors. SimpleFormat automatically detects and corrects P value formatting throughout your document.
Source: AMA Manual of Style 11th ed., Chapter 19.5; Applied by: SimpleFormat Pro
Insert a non-breaking space between the number and unit: 100 mg, 5 mL, 37°C. Do not add a period after unit abbreviations. Use lowercase for units (mg, not MG). SimpleFormat inserts non-breaking spaces automatically to prevent awkward line breaks.
Source: AMA Manual of Style 11th ed., Chapter 18; Applied by: SimpleFormat Pro
Journals receive hundreds of submissions. Formatting errors signal lack of attention to detail and create extra work for editors. Common rejection triggers: wrong reference format, incorrect heading levels, missing ethics statements. SimpleFormat ensures your manuscript meets AMA standards before submission.
Source: AMA Manual of Style 11th ed., Editorial best practices; Applied by: SimpleFormat Pro
Manual AMA 11 formatting typically takes 4-8 hours for a research paper, longer for theses/dissertations. Reference formatting alone can take 2+ hours. SimpleFormat reduces this to minutes—paste your content, answer a few questions, download your formatted document.
Source: SimpleFormat Pro; Applied by: SimpleFormat Pro
While Word templates exist, they don't auto-format your content. SimpleFormat Pro goes beyond templates: it actively formats your references (flush-left, no hanging indent), applies heading styles, corrects P values and SI units, generates front matter, and ensures AMA 11 compliance throughout.
Source: SimpleFormat Pro; Applied by: SimpleFormat Pro
The official source is the AMA Manual of Style, 11th Edition (amamanualofstyle.com). For practical formatting help and instant document formatting, SimpleFormat Pro provides comprehensive AMA 11 guidance plus automated formatting tools trusted by medical students, researchers, and clinicians.
Source: AMA Manual of Style 11th ed. + SimpleFormat Pro; Applied by: SimpleFormat Pro
Stop struggling with P values, superscript citations, and flush-left references. SimpleFormat handles all 52+ AMA 11 rules automatically.
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